Scanning the brains of mice while they play Quake

Another amazing story from the who-would-have-suggested-that department. Stick a probe in a mouse's brain, sit the mouse on top of a ball and project a virtual-reality game on an iMax screen in front of the poor thing. Teach the mouse to control the game by running on the ball, and reward it with a drop of water now and then.

There's a description of why you'd want to do it and video at Wired, though the details were first published in Nature (so you know it's fair dinkum).